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On the Algorithmic Tractability of Single Nucleotide Polymorphism (SNP) Analysis and Related Problems

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Description

Diplomarbeit, die am 23.09.2003 erfolgreich an einer Universität in Deutschland im Fachbereich Informatik 17 eingereicht wurde. Abstract: This work brings together two areas of science-biology and informatics-that have only recently been connected in the emerging (and vastly growing) research field of Bioinformatics. In order to achieve a common basis for Parts 2 and 3 of this work, Part 1 intends to introduce the computer scientist to the relevant biological background and terminology (Chapter 2), and to familiarize the biologist with the relevant topics from theoretical computer science (Chapter 3). Chapter 2 first introduces some terminology from the field of genetics, thereby defining SNPs. We then motivate the analysis of SNPs by two applications, i.e. the analysis of evolutionary development and the field of pharmacogenetics. Especially the field of pharmacogenetics is capable of having an enormous impact on medicine and the pharmaceutical industry in the near future by using SNP data to predict the efficacy of medication. Chapter 3 gives a brief introduction to the field of computational complexity. We will see and motivate how algorithms are analyzed in theoretical computer science. This will lead to the definition of "complexity classes", introducing the class NP which includes computationally hard problems. Some of the hard problems in the class NP can be solved efficiently using the tool of fixed-parameter tractability, introduced at the end of this chapter. An important application of SNP data is in the analysis of the evolutionary history of species development (phylogenetic analysis - part two - chapters 4 and 5). As will be made plausible in Chapter 5 using SNP data is-in many ways-superior to previous approaches of phylogenetic analysis. In order to analyze the development of species using SNP data, an underlying model of evolution must be specified. A popular model is the so-called perfect phylogeny, but the construction of this phylog...

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
01 January 2003
Listed Since
06 February 2009

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