Mass Spectrometry Studies of DNA-Directed Alkylating Agents: The Study of Drug Binding Position on the DNA using MALDI and ESI Mass Spectrometry Instrument - Image 1

£71.00

LAP Lambert Academic Publishing Mass Spectrometry Studies of DNA-Directed Alkylating Agents: The Study of Drug Binding Position on the DNA using MALDI and ESI Mass Spectrometry Instrument

Name: Mass Spectrometry Studies of DNA-Directed Alkylating Agents: The Study of Drug Binding Position on the DNA using MALDI and ESI Mass Spectrometry Instrument
Brand: LAP Lambert Academic Publishing
Price: 71.0 GBP
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Pharmacology

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Description

This work is focused on the use of Mass Spectrometry based technique to determine the site of drug binding and to observe the chemical reactions that occur during ligand-DNA interaction. Such approach is useful and has great potential in aiding DNA targeted drug design in terms of assessing the ligand DNA cross-linking ability, sequence specificity and to certain extent, degree of reactivity for a particular binding site. This work is part of a wider effort in developing drugs that target the minor groove region of the DNA which has been known to be invisible to DNA repair enzymes, a common problem that leads to cancer drug resistance. Mass spectrometry has many advantages in comparison to the conventional techniques applied in DNA targeted drug design. It can provide detail insights into the chemistry of drug-DNA interactions at high level of accuracy and sensitivity.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3838324331
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 13 November 2009
Listed Since: 27 November 2009

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LAP Lambert Academic Publishing Mass Spectrometry Studies of DNA-Directed Alkylating Agents: The Study of Drug Binding Position on the DNA using MALDI and ESI Mass Spectrometry Instrument

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