Virus and RNA Silencing: Polerovirus P0 and its mechanism of action in host plant - Image 1

£70.00

LAP Lambert Academic Publishing Virus and RNA Silencing: Polerovirus P0 and its mechanism of action in host plant

Name: Virus and RNA Silencing: Polerovirus P0 and its mechanism of action in host plant
Brand: LAP Lambert Academic Publishing
Price: 70.0 GBP
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Biological Science

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Description

The poleroviruses are an agronomically important genus of plant viruses which can infect a wide range of hosts. Their genome is a single-stranded plus-sense RNA. The 5’-terminal ORF encodes the 29 kDa protein P0, a strong suppressor of Post- Transcriptional Gene Silencing (PTGS), an important antiviral defense system in plants. I have investigated the mechanism of action of P0 in suppression of RNA silencing. Our data support a model in which P0 acts as an F-box protein, recruiting the post-translational modification system to overcome the post-transcriptional gene silencing system. In this model P0 interacts with SKP to constitute a SCFP0 complex which presumably addresses ARGONAUTE1 that is the slicer protein in the RNA-induced silencing complex (RISC), for ubiquitination and degradation by 26S proteasome. This would be the first example of a suppressor of RNA silencing that acts in an SCF complex to promote degradation of an essential component of the silencing pathway, thereby, inhibiting the plant antiviral defense.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3838311507
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Biological Science
Domain: Amazon UK
Release Date: 21 May 2010
Listed Since: 19 September 2009

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LAP Lambert Academic Publishing Virus and RNA Silencing: Polerovirus P0 and its mechanism of action in host plant

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