£42.00

It has never been this cheap. We have no record of a lower price.

£42 today · cheaper than every other day in the last 3 months

LAP Lambert Academic Publishing Development of Tolerance and Dependence in Barbiturate Use

View at Amazon

Price History & Forecast

Grey patches = out of stock. Cheaper = lower on the chart. Hover for exact prices.

Last 56 days · 56 data points (no recent data)

Historical
Generating forecast…
£42.00 £39.90 £40.74 £41.58 £42.42 £43.26 £44.10 01 August 2026 14 August 2026 28 August 2026 11 September 2026 25 September 2026
View at Amazon ↗

Price data last checked 35 day(s) ago - refreshing...

NEW HERE?

Amazon shows you one price. We show you all of them.

Tosheroon watches Amazon prices so you don't have to. Every product on Amazon has a price history — we make it visible. Set the price you'd actually pay, and we'll email you the second it gets there. No app, no account, one email.

WHAT'S ON THIS PAGE

↑ Price chart
when this has been cheap or pricey
↑ Forecast
where the price is heading next
↓ Statistics
all-time high & low, recent range
↑ Price alert
name your number, we'll email you

Price Distribution

Price distribution over 56 days • 1 price levels

Days at Price
56 days 0 14 28 42 56 £42 Days at Price

Price Analysis

Most common price: £42 (56 days, 100.0%)

Price range: £42 - £42

Price levels: 1 different prices over 56 days

Description

A mathematical model is constructed to study the development of tolerance and dependence to phenobarbital in continuous use. Phenobarbital is a sedative drug targeting the brain. As a side effect, it enhances its own metabolism rate. Also in regular use, the brain adapts to its presence and is rendered less sensitive to the drug with time. This decrease in drug effectiveness urges the user to increase the dose. A feedback loop results as the increased dose affects metabolism and neuroadaptation dynamics. Because adaptive changes persist even after drug intake stops, upon abrupt discontinuation to the drug, the patient experiences unwanted rebound effects. Using the model, we monitor the drug user as he/she develops tolerance. In numerous scenario analyses, we reveal the factors to which the drug user is most sensitive. Then, we search for dosing regimens that facilitate gradual withdrawal from the drug so that rebound effects are avoided. This resarch is a good example of a mathematical modeling approach to a medical phenomenon as it highlights causalities and explains the underlying structures of tolerance and dependence development.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
30 July 2009
Listed Since
31 July 2009

Barcode

No barcode data available

Similar Products You Might Like

A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities
95% match

A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities

Springer

£74.21 19 Sep 2026
LAMOTRIGINE TABLETS: Formulation and In vitro evaluation of Lamotrigine Orally disintegrating tablets and Sustained release tablets
94% match

LAMOTRIGINE TABLETS: Formulation and In vitro evaluation of Lamotrigine Orally disintegrating tablets and Sustained release tablets

LAP Lambert Academic Publishing

£43.00 22 Sep 2026
Antiepileptic Drugs: A Clinician's Manual
94% match

Antiepileptic Drugs: A Clinician's Manual

Oxford University Press

£53.00 11 Sep 2026
Antiepileptic Drugs: Combination Therapy and Interactions
94% match

Antiepileptic Drugs: Combination Therapy and Interactions

Cambridge University Press

£45.06 02 Oct 2026
Peripheral Benzodiazepine Receptors (Neuroscience Perspectives)
94% match

Peripheral Benzodiazepine Receptors (Neuroscience Perspectives)

Elsevier

£122.78 30 Sep 2026
Sleep, Benzodiazepines and Performance: Experimental Methodologies and Research Prospects: 1 (Psychopharmacology Series, 1)
93% match

Sleep, Benzodiazepines and Performance: Experimental Methodologies and Research Prospects: 1 (Psychopharmacology Series, 1)

Springer

£76.42 01 Oct 2026
1,000+ Practice Questions with Rationales for Psychiatric Technician Licensure Examination
93% match

1,000+ Practice Questions with Rationales for Psychiatric Technician Licensure Examination

CREATESPACE

£87.02 18 Sep 2026
β-Carbolines: A Privileged Scaffold for Modern Drug Discovery
93% match

β-Carbolines: A Privileged Scaffold for Modern Drug Discovery

CRC Press

£164.84 26 Aug 2026
Benzodiazepines and GHB: Detection and Pharmacology (Forensic Science and Medicine)
93% match

Benzodiazepines and GHB: Detection and Pharmacology (Forensic Science and Medicine)

Humana

£80.67 25 Sep 2026
Handbook of Drug Interactions: A Clinical and Forensic Guide
93% match

Handbook of Drug Interactions: A Clinical and Forensic Guide

Humana

£164.97 24 Aug 2026
Antiseizure Medications: A Clinician's Manual
93% match

Antiseizure Medications: A Clinician's Manual

Oxford University Press

£74.00 17 Sep 2026
Benzodiazepine Receptor Ligands, Memory and Information Processing: Psychometric, Psychopharmacological and Clinical Issues: 6 (Psychopharmacology Series, 6)
93% match

Benzodiazepine Receptor Ligands, Memory and Information Processing: Psychometric, Psychopharmacological and Clinical Issues: 6 (Psychopharmacology Series, 6)

Springer

£76.47 02 Oct 2026
The Neurobehavioral Treatment of Epilepsy
93% match

The Neurobehavioral Treatment of Epilepsy

Psychology Press

£140.72 24 Sep 2026
Epilepsy Case Studies: Pearls for Patient Care
93% match

Epilepsy Case Studies: Pearls for Patient Care

Springer

£79.99 12 Sep 2026
Cambridge Epilepsy Prescriber's Guide to Antiepileptic Drugs
93% match

Cambridge Epilepsy Prescriber's Guide to Antiepileptic Drugs

Cambridge University Press

£58.44 10 Oct 2026
Wolters Kluwer Yaffe and Aranda's Pediatric Pharmacology
93% match

Wolters Kluwer Yaffe and Aranda's Pediatric Pharmacology

WOLTERS KLUWER HEALTH

£189.01 28 Aug 2026
Neuropsychiatric Symptoms of Epilepsy (Neuropsychiatric Symptoms of Neurological Disease)
93% match

Neuropsychiatric Symptoms of Epilepsy (Neuropsychiatric Symptoms of Neurological Disease)

Springer

£86.71 24 Sep 2026
Elsevier Benzodiazepine-Based Drug Discovery Book
93% match

Elsevier Benzodiazepine-Based Drug Discovery Book

Elsevier

£148.46 05 Sep 2026
Childhood Epilepsy: Language, Learning and Behavioural Complications
93% match

Childhood Epilepsy: Language, Learning and Behavioural Complications

Cambridge University Press

£82.65 23 Sep 2026
BENZODIAZEPINE: Abuse & Therapeutic Uses, Pharmacology & Health Effects (Pharmacology - Research, Safety Testing and Regulation: Substance Abuse Assessment, Interventions and Treatment)
93% match

BENZODIAZEPINE: Abuse & Therapeutic Uses, Pharmacology & Health Effects (Pharmacology - Research, Safety Testing and Regulation: Substance Abuse Assessment, Interventions and Treatment)

£142.99 30 Sep 2026
Side Effects of Drugs Annual (Volume 46)
93% match

Side Effects of Drugs Annual (Volume 46)

Elsevier

£199.75 26 Aug 2026