£67.00

OmniScriptum Biomarqueurs HI cérébrale néonatale et inflammation materno-foetale: Recherche de biomarqueurs précoces par SRM 1H haute résolution, approche métabonomique des fluides biologiques (Omn.Pres.Franc.)

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Description

La Leucomalacie Périventriculaire représente la cause principale des incapacités neurologiques et est associée au développement de la paralysie cérébrale dans l'enfance. L'ischémie cérébrale et l’infection intra-utérine ont été proposées comme causes primaires dans la genèse des dommages cérébraux de la substance blanche du nouveau-né. Le but de cette étude était d’explorer, par une approche métabonomique (Spectroscopie de Résonance Magnétique du proton, SRM 1H) les fluides biologiques dans deux modèles animaux. Dans le modèle animal d’hypoxie ischémie, l’étude du liquide céphalorachidien et de l’urine n’a pas permis de mettre en évidence un marqueur diagnostic précoce spécifique de la pathologie pouvant informer sur la sévérité de l’accident cérébral. Dans le modèle d’inflammation in utéro, la présence de marqueurs biologiques de l’inflammation maternelle dans le plasma sanguin et dans le liquide amniotique a été validée et permet d’envisager leurs utilisations pour le diagnostic précoce. Cet ouvrage est destiné aux étudiants du M2 à la thèse ainsi qu’à des lecteurs de disciplines voisines désirant s’informer.

Product Specifications

Format
paperback
Domain
Amazon UK
Publication Date
03 March 2014
Listed Since
26 March 2014

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