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Neohepatozyten als HCV-Infektionssystem: Entwicklung eines Personen-spezifischen Zellkultursystems zur Untersuchung von Hepatitis C Virus Infektionen

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£71.00 £67.45 £68.87 £70.29 £71.71 £73.13 £74.55 25 July 2026 15 August 2026 06 September 2026 28 September 2026 20 October 2026
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88 days 0 22 44 66 88 £71 Days at Price

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Description

Basierend auf der Notwendigkeit eines alternativen Zellsystems für HCV-Studien wurden Monozyten-basierte Neohepatozyten als Personen-spezifisches Infektionssystem getestet. Dabei konnte gezeigt werden, dass Neohepatozyten neben Albumin und den bis dato bekannten HCV-Rezeptoren zudem die Leberzell-spezifische miRNA122 exprimieren. Infektionsexperimente mit HCVpp konnten zudem belegen, dass der Großteil der Neohepatozyten für die virale Infektion zugänglich ist. Humanes AB-Serum war dabei ebenso wie das Polysaccharid DEAE-Dextran in der Lage, die HCVpp-Infektionsfrequenz positiv zu beeinflussen. Die Neutralisation der HCVpp-Infektion durch Rezeptor-spezifische Antikörper zeigte zudem, dass die HCVpp-Infektion in Neohepatozyten über die gleichen Eintrittsfaktoren vermittelt wird wie in Hepatozyten. Humane Neohepatozyten konnten damit als effizientes System identifiziert werden, um den HCV-Zelleintritt Patienten-spezifisch zu untersuchen.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
02 December 2009
Listed Since
07 December 2009

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