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Analytik von Wachstumshormon und Dopingnachweis: Massenspektrometrische Charakterisierung und Entwicklung einer Dopingkontrollmethode

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Description

Humanes endogenes Wachstumshormon wird in der Hypophyse produziert, ist einer der wichtigsten Wachstumsregulatoren im menschlichen Körper und nimmt Einfluss auf unterschiedliche Stoffwechselvorgänge wie Lipolyse oder Proteinanabolismus. Die Verwendung von Wachstumshormon im Sport ist von der Welt Anti- Doping Agentur verboten. Neben einem Überblick über wissenschaftliche Erkenntnisse der Physiologie und Biochemie des Wachstumshormons beschreibt das Buch die massenspektrometrische Charakterisierung endogener Wachstumshormonvarianten und leistet einen Beitrag zur Auklärung der Struktur dieses Proteins. Außerdem wird die Entwicklung einer Dopingkontrollprozedur mittels immunologischer Techniken und zweidimensionaler Gelelektrophorese vorgestellt. Die Dopingkontrollmethode eröffnet eine neue Möglichkeit, den bestehenden Assay zu komplementieren und die Bestimmung rekombinanten Wachstumshormons zu optimieren. Die Detektion unterschiedlicher endogener Wachstumshormonformen zeigt außerdem ein mögliches Einsatzfeld der Methode für klinische Zwecke auf.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
17 July 2009
Listed Since
28 August 2009

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