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Tissue Engineering von Knochen mit embryonalen Stammzellen: Untersuchungen zur Eignung muriner embryonaler Stammzellen

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Description

Embryonale Stammzellen (ESC) haben als pluripotente Stammzellen viele Vorteile gegenüber multipotenten adulten Stammzellen oder maturen unipotenten Zellen. Ziel dieser Studie war es, die Eignung dieser Zellen für das Tissue Engineering von Knochen näher zu analysieren. Neben der Frage nach dem geeigneten Differenzierungsmedium wurde der Differenzierungsprozess hinsichtlich seines zeitlichen Verlaufs und des Expressionsmusters wichtiger osteoblastentypischer Gene analysiert. Zudem wurden erste Erkenntnisse über die Beteiligung verschiedener Transkriptionsfaktoren gewonnen. Verschiedene Biomaterialien wurden auf ihre Kompatibilität mit ESC überprüft. Schließlich wurden erstmalig ESC in Mikromassenkulturen osteogen kultiviert und differenziert.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
15 January 2009
Listed Since
27 January 2009

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