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£65.57

VDM Verlag Dr. Mueller e.K. Phylogenetic Analysis of Viral Quasispecies

Name: Phylogenetic Analysis of Viral Quasispecies
Brand: VDM Verlag Dr. Mueller e.K.
Price: 65.57 GBP
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Diseases & Disorders

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Description

A new approach in the analysis of viral evolution is presented in this book, an approach that merges Phylogenetic analysis and Bioinformatic techniques. Patterns of viral evolution are inferred from serially-sampled sequence data, i.e., sequence data obtained from strains isolated at consecutive time points from a single patient or host. Traditional phylogenetic methods assume a tree-like evolutionary model, while many RNA viruses have the capacity to exchange genetic material with one another using a process called recombination. A genealogy involving recombination is best described by a network structure. A more general approach was implemented in a new computational tool, Sliding MinPD, one that is mindful of the sampling times of the input sequences and that reconstructs the viral evolutionary relationships in the form of a network structure with implicit representations of recombination events. The underlying network organization reveals unique patterns of viral evolution and could help explain the emergence of disease-associated mutants and drug-resistant strains, with implications for patient prognosis and treatment strategies.

Product Specifications

Brand: VDM Verlag Dr. Mueller e.K.
Format: paperback
ASIN: 383643458X
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Diseases & Disorders
Domain: Amazon UK
Release Date: 07 January 2008
Listed Since: 17 January 2008

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VDM Verlag Dr. Mueller e.K. Phylogenetic Analysis of Viral Quasispecies

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