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Springer Serotonin und akustisch evozierte Potentiale: Auf der Suche nach einem verlässlichen Indikator für das zentrale 5-HT-System: 109 (Monographien aus dem Gesamtgebiete der Psychiatrie, 109)

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Description

Bislang steht für das serotonerge System beim Menschen kein valider Indikator zur Verfügung. Es gibt nun verschiedene Hinweise darauf, dass die Lautstärkeabhängigkeit der akustisch evozierten N1/P2-Komponente (LAAEP) als ein solcher Indikator in Frage kommt: Eine starke LAAEP zeigt eine niedrige serotonerge Aktivität, eine schwache LAAEP zeigt eine hohe serotonerge Aktivität. Ziel der hier beschriebenen Untersuchungen war es, diese Hypothese zu untermauern. Die Befunde belegen den Zusammenhang von LAAEP und dem serotonergen System und seine Spezifität. Entscheidend ist dabei auch die Nützlichkeit der LAAEP als Indikator des serotonergen Systems bei wichtigen klinisch-psychiatrischen Fragestellungen, beispielsweise der Prädiktion der individuellen Ansprechwahrscheinlichkeit auf Antidepressiva oder Rezidivprophylaktika. Eine Reihe von erfolgreichen Studien hierzu dürfte die baldige Einführung der LAAEP in die klinische Praxis rechtfertigen.

Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
05 July 2005
Listed Since
15 February 2007

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