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LAP Lambert Academic Publishing Synthesis and Biological Activities of Clubbed Triazole-Pyrazoles

Name: Synthesis and Biological Activities of Clubbed Triazole-Pyrazoles
Brand: LAP Lambert Academic Publishing
Price: 44.0 GBP
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Pharmacology

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Description

In this book, new methods were developed for the synthesis of 1,2,4-triazole clubbed with pyrazoles in the single molecular frame. In the first part of the study, the chalcones of the 3,5-diphenyl-1,2,4-triazoles were investigated as new ways for the synthesis of the target compounds. After that isonicotinic acid hydrazide were reacted with the chalcones in slightly acidic medium to obtained the target compounds in good to excellent yields. Subsequently, the same reactions were carried out with hydrazine hydrate, which furnished corresponding pyrazoles in good yields. The structures of all the substituted pyrazoles were confirmed by IR, 1H-NMR, Mass spectroscopy and elemental analysis. All the reactions were monitored by TLC. In the second part of the study, the final derivatives were screened for their antinociceptive and antimicrobial activity. The antinociceptive activity was carried out by central and peripheral analgesic methods. study the antimicrobial property by liquid broth method. All compounds were exhibited analgesic activity at a dose level of 100 mg/kg. All the substituted pyrazoles were exhibited powerful antimicrobial activity at a MIC range of 62.50- 15.62 µg/ml

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3659791660
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 18 May 2017
Listed Since: 12 June 2017

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LAP Lambert Academic Publishing Synthesis and Biological Activities of Clubbed Triazole-Pyrazoles

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LAP Lambert Academic Publishing Synthesis and Biological Activities of Clubbed Triazole-Pyrazoles

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