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LAP Lambert Academic Publishing Molecular Insight into Human Platelet Antigen HPA-1 Polymorphism

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Description

Human platelet HPA-1 polymorphism is embedded in the N-terminal plexin/semaphorin/integrin (PSI) domain of the β3 chain of the platelet integrin αIIbβ3. HPA-1 polymorphism is responsible for neonatal alloimmune thrombocytopenia (NAITP). T-helper response drives anti-HPA-1a production and the putative dominant T-helper epitope is likely to be an important contributory factor in the immunogenicity of HPA-1a. This book provides detailed insight into the molecular mechanism behind of anti-HPA-1a platelet alloimmunization.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
12 December 2013
Listed Since
13 December 2013

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