Development of Antiviral Innate Immunity in Mouse Embryonic Stem Cells - Image 1

£67.00

LAP Lambert Academic Publishing Development of Antiviral Innate Immunity in Mouse Embryonic Stem Cells

Name: Development of Antiviral Innate Immunity in Mouse Embryonic Stem Cells
Brand: LAP Lambert Academic Publishing
Price: 67.0 GBP
Availability: InStock

Biological Science

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Description

Embryonic stem cells have been recognized as a promising cell source for regenerative medicine. However, increasing evidence indicates that ESC-derived cells generated by the current differentiation methods are not fully functional. It is recently recognized that ESC-derived cells lack innate immunity to a wide range of infectious agents and inflammatory cytokines. When used in patients, ESC-derived cells would be placed in wounded sites that are exposed to various pathogens and inflammatory cytokines; therefore, their viability and functionality would be significantly compromised if the cells do not have competent immunity. The responses of mESCs to three types of live viruses, La Crosse virus, West Nile virus, Sendai virus, and synthetic viral dsRNA and ssRNA analogs were firstly investigated, in particular their ability to express type I interferons (IFNα and IFNβ). Furthermore, the author asked whether mESCs can respond to type I IFNs, express IFN-stimulated genes and be protected from viral infection as differentiated fibroblasts. These data will be valuable not only for studying development of innate immunity but also for application of ESC for regenerative medicine.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3659394939
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Biological Science
Domain: Amazon UK
Release Date: 06 March 2015
Listed Since: 01 April 2015

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LAP Lambert Academic Publishing Development of Antiviral Innate Immunity in Mouse Embryonic Stem Cells

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