In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus: To Prevent Cancer Induce Apoptosis - Image 1

£63.00

LAP Lambert Academic Publishing In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus: To Prevent Cancer Induce Apoptosis

Name: In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus: To Prevent Cancer Induce Apoptosis
Brand: LAP Lambert Academic Publishing
Price: 63.0 GBP
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Pharmacology

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An essential oil from a lemon grass variety of Cymbopogon flexuosus (CFO) and its major chemical constituent sesquiterpene isointermedeol (ISO) were investigated for their ability to induce apoptosis in human leukaemia HL-60 cells because dysregulation of apoptosis is the hallmark of cancer cells. CFO and ISO inhibited cell proliferation with 48 h IC50 of∼30 and 20 g/ml, respectively. Both induced concentration dependent strong and early apoptosis as measured by various end-points, e.g. annexinV binding, DNA laddering, apoptotic bodies formation and an increase in hypo diploid sub-G0 DNA content during the early 6 h period of study. This could be because of early surge in ROS formation with concurrent loss of mitochondrial membrane potential observed. Both CFO and ISO activated apical death receptors TNFR1, DR4 and caspase-8 activity. Simultaneously, both increased the expression of mitochondrial cytochrome c protein with its concomitant release to cytosol leading to caspase-9 activation, suggesting thereby the involvement of both the intrinsic and extrinsic pathways of apoptosis.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3659281662
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 19 October 2012
Listed Since: 27 October 2012

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LAP Lambert Academic Publishing In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus: To Prevent Cancer Induce Apoptosis

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