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LAP Lambert Academic Publishing Chemical Synthesis of Posttranslationally Modified Proteins: From Chemistry to Biology

Name: Chemical Synthesis of Posttranslationally Modified Proteins: From Chemistry to Biology
Brand: LAP Lambert Academic Publishing
Price: 50.0 GBP
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Chemistry

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Description

Many proteins undergo extensive posttranslational modifications (PTMs), such as methylation, acetylation, phosphorylation, glycosylation and ubiquitination. To elucidate the roles of these PTMs, it is necessary to generate homogeneously modified proteins. In this book, we are going to introduce the recently developed chemical synthetic methods for the synthesis of proteins with certain PTM(s). First, we introduce a ligation/S-alkylation approach for the semisynthesis N-terminal tail acetylated proteins. Next, we also introduce the dual native chemical ligation at lysine method for the synthesis of ubiquitinated peptides and proteins. Finally, we introduce a novel N-to-C sequential ligation method for protein total synthesis. These methods developed have dramatically promoted protein PTM research.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3659247529
Category: Books > Subjects > Science, Nature & Maths > Chemistry
Domain: Amazon UK
Release Date: 19 September 2012
Listed Since: 23 September 2012

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LAP Lambert Academic Publishing Chemical Synthesis of Posttranslationally Modified Proteins: From Chemistry to Biology

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