New Prespectives for Type 2 Diabetes Management: Evaluation of L-cysteine as an adjuvant therapy in type 2 diabetes mellitus - Image 1

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GRIN Verlag New Prespectives for Type 2 Diabetes Management: Evaluation of L-cysteine as an adjuvant therapy in type 2 diabetes mellitus

Name: New Prespectives for Type 2 Diabetes Management: Evaluation of L-cysteine as an adjuvant therapy in type 2 diabetes mellitus
Brand: GRIN Verlag
Price: 61.9 GBP
Availability: InStock

Allied Health Professions

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Master's Thesis from the year 2012 in the subject Medicine - Therapy, grade: A, University of Alexandria (Medical Research Institute - Alexandria University), language: English, abstract: Increasing evidence has established causative links between obesity, chronic inflammation and insulin resistance; the core pathophysiological feature in type 2 diabetes mellitus. This study was designed to examine whether the combination of L-cysteine and metformin would provide additional benefits in reducing oxidative stress, inflammation and insulin resistance in streptozotocin-induced type 2 diabetes in rats. Male Wistar rats were fed a high-fat diet (HFD) for 8 weeks to induce insulin resistance, after which they were rendered diabetic with low-dose streptozotocin. Diabetic rats were treated with metformin (300 mg/kg/day), L-cysteine (300 mg/kg/day) and their combination along with HFD for another 2 weeks. Control rats were fed normal rat chow throughout the experiment. At the end of treatment, fasting blood glucose, fasting serum insulin, homeostasis model assessment-insulin resistance index (HOMA-IR) and serum free fatty acids (FFAs) were measured. Serum levels of the inflammatory markers; monocyte chemoattractant protein-1 (MCP-1), C-reactive protein (CRP) and nitrite/nitrate were also determined. The liver was isolated and used for determination of malondialdehyde (MDA), reduced glutathione (GSH), caspase-3 and cytochrome c levels. The hypoglycemic effect of the combination therapy exceeded that of metformin and L-cysteine monotherapies with more improvement in insulin resistance. All treated groups exhibited significant reductions in serum FFAs, oxidative stress and inflammatory parameters, caspase-3 and cytochrome c levels compared to untreated diabetic rats with the highest improvement observed in the combination group. In conclusion, the present results clearly suggest that L-cysteine can be strongly considered as an adjunct to metformin in management of type 2 diabet

Product Specifications

Brand: GRIN Verlag
Format: paperback
ASIN: 3656636877
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Allied Health Professions
Domain: Amazon UK
Release Date: 14 April 2014
Listed Since: 15 April 2014

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GRIN Verlag New Prespectives for Type 2 Diabetes Management: Evaluation of L-cysteine as an adjuvant therapy in type 2 diabetes mellitus

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GRIN Verlag New Prespectives for Type 2 Diabetes Management: Evaluation of L-cysteine as an adjuvant therapy in type 2 diabetes mellitus

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