Current Topics in Microbiology and Immunology: Ergebnisse der Mikrobiologie und Immunitätsforschung Volume 59 - Image 1

£76.42

Springer Current Topics in Microbiology and Immunology: Ergebnisse der Mikrobiologie und Immunitätsforschung Volume 59

Name: Current Topics in Microbiology and Immunology: Ergebnisse der Mikrobiologie und Immunitatsforschung Volume 59
Brand: Springer
Price: 76.42 GBP
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Immunology

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Description

Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve chan ges in the hemagglutinin and neuraminidase antigens on the surface of the virus. Antigenic drift, which involves gradual changes in the surface antigens of influenza virus, is thought to result from the selection by an immune popula tion of mutant virus particles with altered antigenic determinants. These mutants therefore possess a growth advantage in the presence of antibody (FRAN CIS and MAASSAB, 1965; ARCHETTI and HORSFALL, 1950; HAMRE et aI., 1958). It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in amino acid sequence in the polypeptides of the hem agglutinin subunits (LAVER and WEBSTER, 1968) and it is likely that antigenic drift in the neuraminidase occurs by the same mechanism.

Product Specifications

Brand: Springer
Format: paperback
ASIN: 3642654460
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Diseases & Disorders > Immunology
Domain: Amazon UK
Release Date: 15 November 2011
Listed Since: 13 July 2012

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Springer Current Topics in Microbiology and Immunology: Ergebnisse der Mikrobiologie und Immunitätsforschung Volume 59

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