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£77.17

Springer Mitochondrial Diseases: Models and Methods

Name: Mitochondrial Diseases: Models and Methods
Brand: Springer
Price: 77.75 GBP
Availability: InStock

General Medical Issues

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Product Description For those like me who witnessed the beginning of the adventure of human mitochon drial pathology, one can only be astounded by the extent and unexpectedness of what the field has come to offer. Extent because nobody could have imagined the sheer size of the domain. Unexpectedness because hitherto it was impossible to imagine the clinical polymorphism that this pathology would represent. The starting point was clear. Initially, there was the exceptional, and for a long time unique, observation of euthyroidian hypermetabolism that Luft and colleagues analyzed remarkably in biochemical and clinical terms. Thereafter, there was the support provided by the electron microscopy studies of Afzelius, and the very first visualization of mitochondrial abnormalities. That was way back in 1958. A few years later, progress in the cytology and cytochemistry of skeletal muscle tissue was to provide the means of detecting such abnormalities by examining sections with light microscopy. The colorful term "ragged red fibers", coined by W. K. Engel, became uni versally accepted, and this typical aspect with Gomori trichrome stain was to throw light on the frequency with which these mitochondrial abnormalities could occur under pathological conditions which, until then, had remained a total mystery regard ing their mechanism: syndromes such as the ocular myopathies with their descending evolution and the oculocraniosomatic syndromes. We were at the beginning of the 1970s. From the Back Cover This volume covers the molecular aspects of mitochondrial disorders and their diagnosis with particular emphasis on the mitochondrial tRNA structure and its various mutations. It further describes some key nuclear-encoded proteins involved in energy transduction and presents new aspects of mitochondrial DNA, e.g. its in vivo conformational changes, and models of deletions and partition. Moreover, it discusses the involvement of mitochondria in apoptosis, hormonal response and ageing. This volume also investigates the precise molecular import mechanisms of particular proteins and specific tRNAs into plants and yeast mitochondria relevant to human diseases.

Product Specifications

Brand: Springer
Format: paperback
ASIN: 3642641660
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > General Medical Issues
Domain: Amazon UK
Release Date: 30 September 2011
Listed Since: 12 July 2012

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Springer Mitochondrial Diseases: Models and Methods

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