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Springer Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy (Springer Theses)

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Description

This book uses an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules, using electron paramagnetic resonance (EPR) spectroscopy. From the Back Cover In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.

Product Specifications

Format
paperback
Domain
Amazon UK
Publication Date
22 February 2014
Listed Since
13 February 2014

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