£144.96

Springer Bispecific Antibodies

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£174.97 £134.89 £143.63 £152.38 £161.12 £169.87 £178.61 09 June 2024 06 November 2024 05 April 2025 02 September 2025 31 January 2026

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219 days 24 days 80 days 14 days 55 days 22 days · current 184 days 4 days 0 55 110 164 219 £139 £141 £142 £143 £144 £145 £146 £175 Days at Price

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Most common price: £139 (219 days, 36.4%)

Price range: £139 - £175

Price levels: 8 different prices over 602 days

Description

The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
13 December 2014
Listed Since
14 December 2014

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