Cancer Immunology and Immunotherapy: 344 (Current Topics in Microbiology and Immunology, 344) - Image 1

£146.52

Springer Cancer Immunology and Immunotherapy: 344 (Current Topics in Microbiology and Immunology, 344)

Name: Cancer Immunology and Immunotherapy: 344 (Current Topics in Microbiology and Immunology, 344)
Brand: Springer
Price: 146.52 GBP
Availability: InStock

Immunology

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Description

The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

Product Specifications

Brand: Springer
Format: paperback
ASIN: 3642267882
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Diseases & Disorders > Immunology
Domain: Amazon UK
Release Date: 29 May 2013
Listed Since: 23 May 2013

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Springer Cancer Immunology and Immunotherapy: 344 (Current Topics in Microbiology and Immunology, 344)

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