Springer Uncultivated Microorganisms: 10 (Microbiology Monographs, 10)

Product Description More than 99 per cent of microbial species refuse to grow in the laboratory. This volume analyzes why, and presents state-of-the-art ways of "outsmarting" uncultivated microorganisms as well as applications of the new insights into medicine and biotechnology. From the Back Cover The number of existing microbial species may be in the millions, but only a few thousand have been isolated in pure culture and described. The principal reason for this tremendous disparity is that, mysteriously, over 99% of all environmental microorganisms refuse to grow in the laboratory. The phenomenon of microbial uncultivability has been recognized as one of the main challenges for basic and applied microbiology, and finding a way to access this uncultivated microbial majority may change many aspects of biology and biotechnology as we know them today. This volume describes the discovery of the phenomenon, the current hypotheses on its physiological and molecular nature, state-of-the-art approaches to "outsmarting" the uncultivated microorganisms, and the importance of the uncultivated microbial majority in medicine and biotechnology. It reveals the hidden universe of uncultivated microorganisms, their unparalleled diversity and enormous potential for application.