Springer Biophysical Aspects of Transmembrane Signaling: 8 (Springer Series in Biophysics, 8)

Writing or editing a book on a very topical field of science is always a great challenge,since by the time the book is published some of the newest and latest findings might be obsolete compared with results reported in the most current issues of various high-level journals. Nevertheless,stimulating good books describe complicated systems and int- relationships and provide a broad spectrum of material for talented researchers who may find new inspiration from a joint presentation of correlated data. Of course,an editor cannot rank his own book. However,in this case,the contrib- ing authors have high scientific standards and well-known achievements which speak for themselves. Transmembrane signaling has many different forms and biochemical and biophysical details. However,the final outcome of transmembrane signaling at the cellular level elucidates some cellular functions, which are at the center of se- defense, alimentation, escape reactions, etc. Transmembrane signaling can be studied best in the immune system,in particular in lymphocytes,the main cel- lar carriers of immune defense. The different chapters are independent studies, written by well-known experts in their particular fields. Some chapters include the authors' very recent data, generalized, on the one hand, to provide und- standable material for those who are interested in the field but not experts. On the other hand,the current data and novel efforts to unify biochemical and bioph- ical events in a physiological description provide interesting reading for experts as well. From the Back Cover Transmembrane signaling is one of the most significant cell biological events in the life and death of cells in general and lymphocytes in particular. Until recently biochemists and biophysicists were not accustomed to thinking of these processes from the side of a high number of complex biochemical events and an equally high number of physical changes at molecular and cellular levels at the same time. Both types of researchers were convinced that their findings are the most decisive, having higher importance than the findings of the other scientist population. Both casts were wrong. Life, even at cellular level, has a number of interacting physical and biochemical mechanisms, which finally build up the creation of an "excited" cell that will respond to particular signals from the outer or inner world. This book handles both aspects of the signalling events, and in some cases tries to unify our concepts and help understand the signals that govern the life and death of our cells. Not only the understanding, but also the interference (e.g. medication) may depend on the full knowledge of both sides. These above statements are supported by the application of highly diverse physical and biochemical technologies demonstrated and explained by experts who are pioneers of their particular scientific field. About the Author Sándor Damjanovich initially studied medicine, and after he obtained his MD, he reoriented his focus in sciences and studied physics. After obtaining his three degrees (MD, Ph.D. and D.Sc) in Hungary, he travelled around the world studying and doing research in spectroscopy of proteins, molecular and cell biology of transmembrane signalling, and different aspects of membrane biophysics. While most of the time he preferentially applied luminescence methods, he also used other methods of investigation including flow cytometry, resonance energy transfer, steady state and time resolved fluorescence and phosphorescence spectroscopy, and most recently scanning force microscopy and near field optical microscopy in order to study cell surface phenomena. He and his co-workers have described a number of molecular patterns at the membrane of lymphocytes and other cells and are proponents of the belief that dynamic cell surface patterns and receptor superstructures govern immune processes and pharmacological interactions at the