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VDM Verlag Funktionsuntersuchung eines Tumorsuppressors: Ras-Assoziationsdomäne Familie 1 Variante A (RASSF1A) in der Krebsentstehung

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Description

Die Ras Assoziationsdomäne Familie 1 umfasst eine Gruppe von Proteinen mit einer Ras-Assoziationsdomäne, die eine Interaktion mit Ras ermöglicht. Das RASSF1 Gen ist auf Chromosom 3p21.3 lokalisiert. Es existieren sieben alternativ gespleißte Transkripte (RASSF1A-RASSF1G), wobei RASSF1A, RASSF1C und RASSF1F die drei Hauptformen darstellen. RASSF1A und RASSF1F werden im Normalgewebe expremiert, aber die Transkripte fehlen in einigen Krebszelllinien. Das RASSF1C Transkript wird sowohl in Normal-, als auch in Tumorgewebe expremiert. Ziel dieser Arbeit war es, den Wirkungsmechanismus des Tumorsuppressors RASSF1A zu charakterisieren. Neben dem möglichen Einfluss von RASSF1A auf die Zellproliferation, den Zellzyklus und die Apoptose, sollte auch die Lokalisation von RASSF1A zu Cytoskelettstrukturen analysiert werden.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
10 September 2009
Listed Since
11 September 2009

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