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VDM Verlag PHARMACOLOGICAL ACTIVITY DRIVEN SYNTHESES OF ORGANIC COMPOUNDS: DEDICATED TO MY PARENTS FOR THEIR COUNTLESS PRAYERS

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Description

ShorttitleThe research work reported in this book is consists of synthesis of pharmacologically active compounds and the modification of their structure according to the result of pharmacological screening. These compounds belongs to the classes 1,3,4-oxadiazole-2(3H)-thione, 1,3,4-thiadiazole-2 (3H)-thione, 1,3,4-oxadiazin-4H-5(6H)-one, 4-amino- 2,4-dihydro-3H-1,2,4-triazole-3-thione and 2- imidazoline. The biological activities associated with 1,3,4-oxadiazole-2(3H)-thione which initiate us to synthesize these heterocyclic compounds are discussed in chapter 1. All these compounds and some of their intermediates were screened for different biological activities including bactericidal, fungicidal, phytotoxic, cytotoxic, urease inhibitory activity and leishmanicidal activities and as expected most of them had exhibited moderate to good activities.The most important result is the evaluation of the 1,3,4-oxadiazole-2(3H)-thione, 1,3,4-thiadiazole-2(3H)-thione and 4-amino-4H-1,2,4- triazol-3-thione as potential inhibitor of the enzyme urease.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
21 July 2009
Listed Since
26 July 2009

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