Photodynamic Therapy of Vulval Neoplasias and Dysplasias: Design and Evaluation of Bioadhesive Photosensitiser Delivery Systems - Image 1

£70.00

VDM Verlag Photodynamic Therapy of Vulval Neoplasias and Dysplasias: Design and Evaluation of Bioadhesive Photosensitiser Delivery Systems

Name: Photodynamic Therapy of Vulval Neoplasias and Dysplasias: Design and Evaluation of Bioadhesive Photosensitiser Delivery Systems
Brand: VDM Verlag
Price: 70.0 GBP
Availability: InStock

Pharmacology

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Description

This book describes the design, physicochemical characterisation and clinical evaluation of bioadhesive drug delivery systems for photodynamic therapy of difficult-to-manage vulval neoplasias and dysplasias. In photodynamic therapy (PDT), a combination of visible light and a sensitising drug causes the destruction of selected cells. ALA is commonly delivered to the vulva using creams or solutions, which are covered with an occlusive dressing to aid retention and enhance drug absorption. Such dressings are poor at staying in place at the vulva, where shear forces are high in mobile patients. To overcome the problems associated with delivery of ALA to the vulva, we produced a bioadhesive patch by a novel laminating procedure. The ALA loading was 38 mg cm-2. Patches were shown to release more ALA over 6 hours than the proprietary cream. The ALA concentration in tissue at 2.375 mm was an order of magnitude greater than that found to be cytotoxic to HeLa cells. Clinically, the patch was used in successful PDT of vulval intraepithelial neoplasia, lichen sclerosus, squamous hyperplasia, Paget?s disease and vulvodynia. About the Author Dr Ryan Donnelly is Lecturer in Pharmaceutics at Queen's University Belfast.Dr Donnelly's research interests are centered on transdermal and topical drug delivery. He has authored over 150 publications, including around 50 full papers.

Product Specifications

Brand: VDM Verlag
Format: paperback
ASIN: 363913155X
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 06 March 2009
Listed Since: 02 April 2009

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VDM Verlag Photodynamic Therapy of Vulval Neoplasias and Dysplasias: Design and Evaluation of Bioadhesive Photosensitiser Delivery Systems

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