£69.99

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£70 for 54 days straight · last change was Aug 2026

VDM Verlag Photodynamic Therapy of Vulval Neoplasias and Dysplasias: Design and Evaluation of Bioadhesive Photosensitiser Delivery Systems

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£70.00 £65.19 £66.24 £67.29 £68.34 £69.39 £70.44 25 July 2026 15 August 2026 06 September 2026 28 September 2026 20 October 2026
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Price distribution over 88 days • 2 price levels

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7 days 81 days · current 0 20 41 61 81 £66 £70 Days at Price

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Most common price: £70 (81 days, 92.0%)

Price range: £66 - £70

Price levels: 2 different prices over 88 days

Description
This book describes the design, physicochemical characterisation and clinical evaluation of bioadhesive drug delivery systems for photodynamic therapy of difficult-to-manage vulval neoplasias and dysplasias. In photodynamic therapy (PDT), a combination of visible light and a sensitising drug causes the destruction of selected cells. ALA is commonly delivered to the vulva using creams or solutions, which are covered with an occlusive dressing to aid retention and enhance drug absorption. Such dressings are poor at staying in place at the vulva, where shear forces are high in mobile patients. To overcome the problems associated with delivery of ALA to the vulva, we produced a bioadhesive patch by a novel laminating procedure. The ALA loading was 38 mg cm-2. Patches were shown to release more ALA over 6 hours than the proprietary cream. The ALA concentration in tissue at 2.375 mm was an order of magnitude greater than that found to be cytotoxic to HeLa cells. Clinically, the patch was used in successful PDT of vulval intraepithelial neoplasia, lichen sclerosus, squamous hyperplasia, Paget?s disease and vulvodynia.

Product Specifications
Brand
VDM Verlag
Format
paperback
ASIN
363913155X
Category
Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain
Amazon UK
Release Date
06 March 2009
Listed Since
02 April 2009

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No barcode data available

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