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VDM Verlag Untersuchung der Neuropathologie konditionaler Mausmodelle des Morbus Parkinson: Reversibilitäts-Analyse des Einflusses von alpha-Synuclein in vivo

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Description

Das alpha-Synuclein (SNCA) spielt in der Pathogenese der Parkinson-Erkrankung eine zentrale Rolle. Die Krankheit basiert auf einer progressiven Neuropathologie, die zu motorischen Störungen und oftmals Riechstörung und kognitive Einbussen führt. Es ist nicht bekannt ob der Verlauf der Neuropathologie gestoppt oder umgekehrt werden kann. In dieser Arbeit wurden deshalb konditionale Mausmodelle analysiert. Mäuse mit WT-SNCA-Expression zeigten nigrale und hippokampale Neurodegeneration, einschließlich einer verminderten Neurogenese, die in einer progredienten motorischen Schwäche und Einbussen im Langzeitgedächtnis resultierten. Das Abschalten der SNCA-Expression führte zu einem Stopp der motorischen Symptomatik jedoch nicht zur Reversibilität. Mäuse mit Expression von mutierten (A30P) SNCA im Riechhirn, zeigten eine Reduktion von Dopamin und im Geruchsstest eine verminderte Angstreaktion und ein erhöhtes Explorationsverhalten; letzteres könnte ein Hauptmerkmal für eine Depression sein. Die Daten legen nahe, dass in frühen Stadien der Parkinson-Krankheit behandelnde Strategien, die gegen SNCA involvierte pathologische Zellwege gerichtet sind, vorteilhaft sind.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
25 October 2013
Listed Since
23 March 2010

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