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VDM Verlag Langzeitergebnisse bei akuter myeloischer Leukämie: Chemotherapie mit Cytosinarabinosid und Idarubicin

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Description

Leukämien sind maligne klonale Neoplasien des hämatopoetischen Systems. Traditionell unterteilt man zwischen akuten und chronischen Leukämien. Die chronischen Leukämien werden heute entsprechend ihrer Biologie entweder den niedrig malignen Lymphomen (CLL - chronisch lymphatische Leukämie) oder dem myeloproliferativen Syndrom (CML - chronisch myeloische Leukämie) zugerechnet. Bei den akuten Leukämien, die im Vergleich zu den chronischen Leukämien häufig einen raschen, gelegentlich foudroyanten Verlauf zeigen, kann man in der Regel nach der Herkunft der malignen Zellen zwischen der lymphatischen (ALL - akute lymphatische Leukämie) und der myeloischen Leukämie (AML - akute myeloische Leukämie) unterscheiden. Die AML ist durch das ungezügelte Wachstum differenzierungs- und reifungsgestörter myeloischer Vorläuferzellen charakterisiert. Mit Infiltration des Knochenmarks wird das Wachstum normaler hämatopoetischer Zellen supprimiert. Unbehandelt führt die hieraus entstehende Anämie, Granulozytopenie und Thrombozytopenie mit der Folge von Infektionen und/oder hämorrhagischen Diathesen rasch zu einem lebensbedrohlichen Krankheitszustand.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
07 December 2008
Listed Since
12 December 2008

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