Neurodegenerative Disorders: Loss of Function Through Gain of Function (Research and Perspectives in Alzheimer's Disease) - Image 1

£92.63

Springer Neurodegenerative Disorders: Loss of Function Through Gain of Function (Research and Perspectives in Alzheimer's Disease)

Name: Neurodegenerative Disorders: Loss of Function Through Gain of Function (Research and Perspectives in Alzheimer's Disease)
Brand: Springer
Price: 92.63 GBP
Availability: InStock

Geriatrics

This is the most expensive it has ever been. Walk away.

£93 today · previous high £93 · all-time low £77

NEW HERE?

Amazon shows you one price. We show you all of them.

Tosheroon watches Amazon prices so you don't have to. Every product on Amazon has a price history — we make it visible. Set the price you'd actually pay, and we'll email you the second it gets there. No app, no account, one email.

WHAT'S ON THIS PAGE

↓ Price chart
when this has been cheap or pricey

↓ Forecast
where the price is heading next

↓ Statistics
all-time high & low, recent range

↑ Price alert
name your number, we'll email you

Price History & Forecast

Grey patches = out of stock. Cheaper = lower on the chart. Hover for exact prices.

Last 55 days • 55 data points (No recent data available)

Historical

Generating forecast...

Price Distribution

Price distribution over 55 days • 3 price levels

Days at Price

Current Price

Price Analysis

Most common price: £82 (35 days, 63.6%)

Price range: £77 - £93

Price levels: 3 different prices over 55 days

Description

Fondation Ipsen sponsored a meeting in Paris in February 2000 on the emerging paradigm-shift in our understanding of the major degenerative diseases which- affect the aging human brain. This book sumarizes our deliberations on some of these major neurodegenerative diseases that are characterized by protein depos- its, and that are due to the pathogenic gain of function of an otherwise normal neuronal protein. For each of the major human neurodegenerative diseases covered in this book -the most prominent being Alzheimer's disease -experimental models are described, including cell culture systems and animal models which range from the round worm, Caenorhabditis elegans, the fruitfly, Drosophila melanogaster, to rodents. Remarkably, in the sporadic forms of these human diseases, only a minor change in the level of production or turn-over of the relevant proteins is sufficient to cause disease in late adult-hood. Neurodegeneration in Alzheimer's disease, for example, usually results in symptoms and signs in the seventh to eighth decades. In contrast, the development of protein deposits in transgenic mice over-expressing the corresponding disease gene parallels the genetic forms of the human diseases in regard to its manifestation occuring half-way through its normal life-span, i. e. about 50 years in humans (the so-called "presenium") and 9 to 12 months in the mouse. Nevertheless, these models have served to elu- cidate many of the pathways underlying the human disease processes, for instance clarifying the neuronal origin of parenchymal and perivascular amyloid in Alzheimer's disease and Creutzfeldt-Jakob disease.

Product Specifications

Brand: Springer
Format: hardcover
ASIN: 3540412182
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Geriatrics
Domain: Amazon UK
Release Date: 13 March 2001
Listed Since: 16 December 2006

Barcode

No barcode data available

Springer Neurodegenerative Disorders: Loss of Function Through Gain of Function (Research and Perspectives in Alzheimer's Disease)

This is the most expensive it has ever been. Walk away.

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

Similar Products You Might Like

Neurodegenerative Diseases: Pathology, Mechanisms, and Potential Therapeutic Targets: 15 (Advances in Neurobiology, 15)

Neurodegenerative Diseases: Molecular and Cellular Mechanisms and Therapeutic Advances (Gwumc Department of Biochemistry and Molecular Biology Annual Spring Symposia)

Alzheimer's Disease: Targets for New Clinical Diagnostic and Therapeutic Strategies (Frontiers in Neuroscience)

The Biology of Alzheimer Disease (Cold Spring Harbor Perspectives in Medicine)

Molecular Mechanisms of Neurodegenerative Diseases (Contemporary Clinical Neuroscience)

Neuroprotection in Alzheimer's Disease

Neurodegeneration and Alzheimer's Disease: The Role of Diabetes, Genetics, Hormones, and Lifestyle

The Ageing Brain: The Neuobiology and Neuropsychiatry of Ageing (Studies on Neuropsychology, Development, and Cognition)

Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders (International Society of Neuropathology Series)

Molecular Biology of Alzheimer's Disease: Genes and Mechanisms Involved in Amyloid Generation

Alzheimer's Disease and Related Disorders: Etiology, Pathogenesis and Therapeutics

Research Progress in Alzheimer's Disease & Dementia: v. 4 (Research Progress in Alzheimer's Disease and Dementia): Volume 4

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms

Macro Roles for MicroRNAs in the Life and Death of Neurons (Research and Perspectives in Neurosciences)

ALZHEIMER'S DISEASE: INSIGHTS INTO LOW MOLECULAR WEIGHT AND CYTOTOXIC AGGREGATES FROM IN VITRO AND COMPUTER EXPERIMENTS - MOLECULAR BASIS OF ... (Molecular Medicine And Medicinal Chemistry)

Handbook of the Neuroscience of Aging

The Molecular and Clinical Pathology of Neurodegenerative Disease

Neurodegenerative Disorders as Systemic Diseases

Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols: 670 (Methods in Molecular Biology, 670)

Pathogenesis of Neurodegenerative Disorders (Contemporary Neuroscience)

Biomarkers for Early Diagnosis of Alzheimer's Disease

Academic Press Cancer Immunotherapy - Volume 164 Book

Neurodegenerative Disorders as Systemic Diseases

Neurodegenerative Diseases: Unifying Principles