Springer Oxygen Transport to Tissue XL: 1072 (Advances in Experimental Medicine and Biology, 1072)

The book contains the refereed contributions from the 45th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) 2017. This volume covers cross-disciplinary work on a broad range of topics related to the dynamics of oxygen transport: microcirculation and vascular medicine; O2 deficiency and its impact on molecular processes in cells and tissues; cellular metabolism and mitochondrial function; multimodal functional imaging; mathematical modeling; the clinical relevance of oxygen supply as well as therapeutic interventions (e.g. in oncology or critical care medicine). The annual meetings of ISOTT bring together scientists from diverse fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. The book includes sections on brain oxygenation and function, NIRS oxygenation measurements, tumor oxygenation, cell metabolism, tissue oxygenation and treatment, methodical aspects of O2 measurements and physicochemical aspects of oxygen diffusion. Chapters 3, 24, 49 and 51 of this book are open access under a CC BY 4.0 license. From the Back Cover The book contains the refereed contributions from the 45th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) 2017. This volume covers cross-disciplinary work on a broad range of topics related to the dynamics of oxygen transport: microcirculation and vascular medicine; O2 deficiency and its impact on molecular processes in cells and tissues; cellular metabolism and mitochondrial function; multimodal functional imaging; mathematical modeling; the clinical relevance of oxygen supply as well as therapeutic interventions (e.g. in oncology or critical care medicine). The annual meetings of ISOTT bring together scientists from diverse fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. The book includes sections on brain oxygenation and function, NIRS oxygenation measurements, tumor oxygenation, cell metabolism, tissue oxygenation and treatment, methodical aspects of O2 measurements and physicochemical aspects of oxygen diffusion. Chapters 3, 24, 49 and 51 of this book are open access under a CC BY 4.0 license. About the Author Oliver Thews is Professor of Physiology at the Martin Luther University Halle-Wittenberg, Germany. He studied medicine at the University of Mainz and worked there at the Institute of Medical Statistics and Documentation as well as at the Institute of Physiology. After a temporary professorship of physiology at the University of Würzburg he moved to the Julius-Bernstein-Institute of Physiology at the University of Halle. His major research field is the role of metabolic parameters such as hypoxia and acidosis on the biological behavior of tumor cells. He is interested in the therapeutic relevance of microenvironmental tissue parameters and the mechanisms by which these parameters act. In addition, his research focusses on functional in vivo imaging using Positron Emission Tomography. He has served as the Secretary of ISOTT since 1999. Joseph C. LaManna is the Jeanette M. and Joseph S. Silber Professor of Brain Sciences at the Case Western Reserve University School of Medicine, Department of Physiology & Biophysics. He is the former chair of the Department of Anatomy at CWRU.  He is a Past President of The Federation of American Societies for Experimental Biology (FASEB), and Secretary of the International Society for Cerebral Blood Blow and Metabolism. He has published over 250 papers on the topic of oxygen and energy metabolism, especially in the field of brain blood flow and metabolism. He has been a member of the International Society for Oxygen Transport to Tissue since 1976, serving as President of the ISOTT in 2009. In 2016 he became the editor in Chief of the ISOTT proceedings. David Harrison is CEO of Microvascular Measurements