Springer Modelling the Toxicity of Nanoparticles: 947 (Advances in Experimental Medicine and Biology, 947)

In today’s nanotechnology and pharmaceutical research, alternative toxicology testing methods are crucial for ethically and commercially sound practice. This book provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios.  Through contributions by academic, industrial, and governmental experts, Modelling the Toxicity of Nanoparticles delivers clear instruction on these methods and their integration and use in risk assessment. Specific topics include the physico-chemical characteristics of engineered nanoparticles, nanoparticle interactions, in vivo nanoparticle processing, and more.  A much-needed practical guide, Modelling the Toxicity of Nanoparticles is a key text for researchers as well as government and industry regulators.  From the Back Cover In today’s nanotechnology and pharmaceutical research, alternative toxicology testing methods are crucial for ethically and commercially sound practice. This book provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios. Through contributions by academic, industrial, and governmental experts, Modelling the Toxicity of Nanoparticles delivers clear instruction on these methods and their integration and use in risk assessment. Specific topics include the physico-chemical characteristics of engineered nanoparticles, nanoparticle interactions, in vivo nanoparticle processing, and more. A much-needed practical guide, Modelling the Toxicity of Nanoparticles is a key text for researchers as well as government and industry regulators. About the Author Dr Lang Tran is the Principal Toxicologist at the Institute of Occupational Medicine. Lang has contributed considerably on the toxicology of inhaled particles and fibres. His early work was in the mathematical modelling of the retention and clearance of man-made mineral fibres and mineral dusts.  He has led the investigation and the risk assessment of inhaled poorly soluble particles which helped NIOSH in establishing the control limit for fine and ultrafine TiO2 aerosol. From his experience with particle toxicology Lang has contributed also in many European Research Projects through the Framework 6 and 7 Programmes. Most notable are the project FP7 ENPRA (Risk Assessment of Engineered Nanoparticles) and FP7 MARINA (Managing Risks of Nanoparticles). Lang is currently the chairman of the COST Action TD1204 MODENA on Modelling the toxicity of nanoparticles. Lang is an editor of the NANOTOXICOLOGY and PARTICLE and FIBRE TOXICOLOGY journals.  He also contributes in the organisation of the NANOTOXICOLOGY Symposium series. Miguel A. Bañares (PhD in Chemistry, University of Salamanca, 1992) is Full Research Professor at ICP Institute for Catalysis, CSIC (Spanish National Research Council), where he joined in 1996 and Associate Editor for Catalysis Today. Was postdoctoral fellow at Lehigh University, PA, and at the University of Notre Dame, IN. Bañares has recently been distinguished by the “Otto Mønsted" Visiting Professorship at DTU University, Denmark (2014) and the FEDER-Region Base de Normandie, “chaire d’excellence” at CNRS Caen, France, during (2013-2015).              He has been Deputy Vice-President of CSIC, Spanish National Research Council (2014-2015), chairman of the Management Committee of COST Action D36 (Molecular structure-performance relationships at the surface of functional materials), 2006-2011 and is Vice-Chairman of the Management Committee of COST Action TD1404 MODENA (Modeling Nanomaterial Toxicity), on toxicity of nanoparticles (2012-2016). He is co-founder of Advanced Dispersed Particles in 2011, a CSIC spin-off company, in 2011