Springer Protein Therapeutics: 21 (Topics in Medicinal Chemistry, 21)

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors From the Back Cover Protein Production in Eukaryotic Cells -- Kripa Ram, Diane Hatton, Sanjeev Ahuja, Jean Bender, Alan Hunter, and Richard Turner Production of Protein Therapeutics in the Quality by Design (QbD) Paradigm -- Anurag S. Rathore and Sumit K. Singh Characterization of Therapeutic Proteins -- E.B. Struble, N. Kirschbaum, J. Liu, E. Marszal, and M. Shapiro Immunogenicity Lessons Learned from the Clinical Development of Vatreptacog Alfa, A Recombinant Activated Factor VII Analog, in Hemophilia with Inhibitors -- Kasper Lamberth, Karin Nana Weldingh, Silke Ehrenforth, Mette Ribel Chehade, and Henrik Ostergaard The Art of Gene Redesign and Recombinant Protein Production: Approaches and Perspectives -- Anton A. Komar