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£109.50
Springer B Cell Receptor Signaling: 393 (Current Topics in Microbiology and Immunology, 393)
Price data last checked 49 day(s) ago - refreshing...
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Last 42 days • 42 data points (No recent data available)
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Price distribution over 42 days • 3 price levels
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Most common price: £110 (22 days, 52.4%)
Price range: £107 - £110
Price levels: 3 different prices over 42 days
Description
Product Description This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases. About the Author Tomohiro Kurosaki, MD, PhD, is a professor at WPI Immunology Frontier Research Center at Osaka University, Japan Jürgen Wienands, PhD, is a professor of Cellular and Molecular Immunology at the University of Göttingen, Germany
Product Specifications
- Brand
- Springer
- Format
- paperback
- ASIN
- 3319798995
- Domain
- Amazon UK
- Release Date
- 30 March 2018
- Listed Since
- 30 March 2018
Barcode
No barcode data available
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