Springer Biliary Disease: From Science to Clinic

This book addresses the current understanding of the diagnosis and management of biliary disease across all ages, with emphasis on how the latest advances in clinical science may be integrated into current and future therapies. The coverage is wide ranging, encompassing congenital and acquired conditions including cholestatic syndromes, biliary atresia, drug-induced cholestasis, primary biliary cholangitis/cirrhosis, primary sclerosing cholangitis, cholangiocarcinoma, gallstone disease, and autoimmune sclerosing cholangitis. With contributions from basic and clinical scientists, the relevance of state-of-the-art mechanistic biology to diagnosis, treatment, and future opportunities for drug design is clearly explained. The balance between science and clinical practice will ensure that this book makes a lasting contribution to the field. A broad readership will find the book easy to access and a rich source of information on current best practice and evolving management strategies. Review “This compact and readable book has a broad ambition to cover the basic science, clinical practice, future therapies and advances in this wide field. … The chapters are well chosen to cover the speciality. The text is well organized and easy to follow and search with paragraph headings. … Photos and graphics are plentiful and colourful. … This will prove to be a very useful textbook and reference for clinicians and other professionals working in the field of biliary disease.” (James Rink, British Journal of Hospital Medicine, Vol. 78 (11), November, 2017) From the Back Cover This book addresses the current understanding of the diagnosis and management of biliary disease across all ages, with emphasis on how the latest advances in clinical science may be integrated into current and future therapies. The coverage is wide ranging, encompassing congenital and acquired conditions including cholestatic syndromes, biliary atresia, drug-induced cholestasis, primary biliary cholangitis/cirrhosis, primary sclerosing cholangitis, cholangiocarcinoma, gallstone disease, and autoimmune sclerosing cholangitis. With contributions from basic and clinical scientists, the relevance of state-of-the-art mechanistic biology to diagnosis, treatment, and future opportunities for drug design is clearly explained. The balance between science and clinical practice will ensure that this book makes a lasting contribution to the field. A broad readership will find the book easy to access and a rich source of information on current best practice and evolving management strategies. About the Author David H. Adams, MD, FRCP, FMedSci is the Pro-Vice-Chancellor, Head of College of Medical and Dental Sciences and Dean of Medicine at the University of Birmingham, UK, as well as Professor of Hepatology and Honorary Consultant Hepatologist. He is an international leader in inflammatory liver disease and immune mechanisms of liver injury and has been at the forefront of developments in liver immunology over the last 20 years.  He has published more than 250 papers and has attracted significant grant income nationally and internationally. His clinical interests are transplant hepatology and autoimmune liver disease.  He has played major leadership roles nationally and internationally.  He has a particular interest in clinical academic careers and chairs the AMS Mentoring working group and has been a member of fellowship panels at MRC, Wellcome Trust and Core and INSERM (France). Laboratory research interests are focused on mechanisms of immune-mediated liver disease. He was made a Fellow of the Academy of Medical Sciences in 2000 and an NIHR senior investigator in 2013.  He has a long-standing interest in understanding how leukocyte-endothelial interactions regulate the development and persistence of chronic inflammation and fibrosis in liver disease and how specific micro-environmental signals determine the positioning, activation and survival of eff