Springer New Frontiers: Extracellular Vesicles: 97 (Subcellular Biochemistry, 97)

The field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implications of EVs in intercellular communication and the significance of biologically active cargo carried within these EVs are further examined. Moreover, the numerous applications of EVs in diagnostics and treatment of diseases are reviewed in detail, particularly their potential as biomarkers and drug delivery vehicles.  Taken together, this book is a compilation of the key implications of EVs that are secreted by virtually all cell types. Readers will gain a perspective into the biology, functions and applications of EVs and their constantly evolving knowledge base. From the Back Cover The field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implications of EVs in intercellular communication and the significance of biologically active cargo carried within these EVs are further examined. Moreover, the numerous applications of EVs in diagnostics and treatment of diseases are reviewed in detail, particularly their potential as biomarkers and drug delivery vehicles.  Taken together, this book is a compilation of the key implications of EVs that are secreted by virtually all cell types. Readers will gain a perspective into the biology, functions and applications of EVs and their constantly evolving knowledge base. About the Author Prof Suresh Mathivanan Suresh Mathivanan completed his PhD in proteomics and bioinformatics at the Institute of Bioinformatics, India and Johns Hopkins University, USA. Suresh joined Ludwig Institute for Cancer Research, Melbourne, Australia for his first postdoctoral position. In 2011, he received a NH&MRC Peter Doherty fellowship to study the role of exosomes in cancer cells. In 2015, he was awarded an ARC DECRA to study the role of exosomes in intercellular communication. Suresh established his own research group in the Department of Biochemistry, La Trobe Institute for Molecular Science (LIMS) at La Trobe University after receiving a LIMS fellowship in 2011. Mathivanan laboratory is focused in exploring exosomes and their role in cancer and intercellular communication. Currently, he is funded by an ARC Future Fellowship (FT2: 2018-2022) to investigate exosome biogenesis. He has authored over 94 papers that are cited more than 20000 times (Google Scholar; July 2020) and has been recognized as a highly cited researcher in 2018 and 2019. Currently, he serves as the Director of the Research Centre for Extracellular Vesicles (RCEV) in La Trobe University. Dr Pamali Fonseka Pamali Fonseka is an early career scientist at the La Trobe Institute for Molecular Science. Dr Fonseka was awarded PhD in Dec 2018 from La Trobe University. Her Ph