Springer Sex-Based Differences in Lung Physiology (Physiology in Health and Disease)

This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology. In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung’s innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease. To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike. From the Back Cover This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology. In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung’s innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease.To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike. About the Author Dr. Patricia Silveyra is a Distinguished Associate Professor, Director of the Biobehavioral Laboratory, and member of the Center for Environmental Medicine, Asthma, and Lung Biology (CEMALB) at the University of North Carolina at Chapel Hill. Her research interests are on sex and gender differences in inflammatory lung disease. She specifically studies mechanisms by which sex hormones control inflammatory responses in the lung using mouse and cell models. Dr. Silveyra has published over 50 scientific articles in peer-reviewed journals. She has served as principal investigator, co-principal investigator, and co-investigator on University-, foundation- and NIH-funded grants. She is a former scholar of the NICHD K12, Building Interdisciplinary Research Careers in Women’s Health (BIRCWH), and the NHLBI Programs to Increase Diversity Among Individuals Engaged in Health-Related Research (PRIDE). Dr. Silveyra was born and raised in Argentina, where she earned her bachelor’s and master’s degrees in Molecular Biology and Biotechnology, and her PhD in Biochemistry, from the University of Buenos Aires. She moved to the United States as postdoctoral fellow and Rotary Ambassadorial Scholar. Dr. Silveyra is a member and co-chair of the National Academies of Sciences, Engineering and Medicine (NASEM) “New Voices” program, and a member of the NASEM Board on Higher Education and Workforce.   Dr. Xenia T. Tigno is the Associate Director for Careers at the Office of Research on Women’s Health, National Institutes of Health, Bethesda, MD. Prior to her current