Springer Ion Transport Across Epithelial Tissues and Disease: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 2 (Physiology in Health and Disease)

This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across  epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases.  This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians. From the Back Cover This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across  epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases.  This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians. About the Author Kirk L. Hamilton was born in Baltimore, Maryland in 1953. He gained his undergraduate (biology/chemistry) and M.Sc. (ecology) degrees from the University of Texas at Arlington. He obtained his Ph.D. at Utah State University under the tutelage of Dr. James A. Gessaman, where he studied incubation physiology of Barn owls. His first post-doctoral position was at the University of Texas Medical Branch in Galveston, Texas under the mentorship of Dr. Douglas C. Eaton where he studied epithelial ion transport, specifically, the epithelial sodium channel (ENaC).  He then moved to the Department of Physiology at the University of Alabama, Birmingham for additional post-doctoral training under the supervision of the late Dr. Dale J. Benos where he further studied ENaC, and non-specific cation channels. He took his first academic post in the Department of Biology at Xavier University of Louisiana in New Orleans (1990-1994). He then joined the Department of Physiology at the University of O