Springer Resistance to Targeted Therapies in Lymphomas: 21 (Resistance to Targeted Anti-Cancer Therapeutics, 21)

Over the past few decades, lymphoma patient outcomes have improved as a result of multidrug chemotherapy and radiation therapy, intensification of treatment, improvement in supportive care, and better imaging and staging systems. Even more recently, there has been tremendous progress in the understanding of cancer cell biology and its microenvironment which has resulted in the development of biologic agents, also called "target" therapies. These therapies are more specific in targeting cancer cells either directly or via enhancement of the immune system. Many clinical studies have focused on biological agents in combination with traditional chemotherapy with the goal of improved outcomes, or reduced acute long term complications that are associated with lymphoma therapy.  This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but will also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs.  Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.  From the Back Cover This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.  About the Author Dr. Ana C. Xavier is an Associate Professor at the Division of Hematology/Oncology, Department of Pediatrics at the University of Alabama at Birmingham (Birmingham, Alabama). She received her medical degree from the University of Sao Paulo, Brazil. She completed her pediatric residency at the Medical University of South Carolina and Pediatric Hematology/Oncology fellowship training at the Wayne State University. Dr Xavier is board certified in Pediatrics and Pediatric Hematology/Oncology and currently serves as Associate Program Director of the Pediatric Hematology/Oncology Fellowship Program at the University of Alabama at Birmingham. She has authored numerous peer-reviewed manuscripts in highly reputed international journals and has presented several abstracts at various national and international conferences. She holds memberships with the American Academy of Pediatrics, American Society of Hematology, American Society of Pediatric Hematology/Oncology and Children’s Oncology Group. Dr. Xavier’s clinical practice includes both pediatric oncology and her research interest focus on the treatment of pediatric patients with lymphoma.   Mitchell S. Cairo is currently the Associate Chairman and Professor (with tenure) in the Department of Pediatrics at New York Medical College (NYMC). His additional current leadership positions include being the Chief of the Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Program Director of the Adult & Pediatric BMT Program,