Woodhead Publishing Formulation Tools for Pharmaceutical Development (Woodhead Publishing Series in Biomedicine)

The tools described in this book also permits the evaluation of the proposed formulation which provides data for a better understanding of the process and the product which supports the development of medicines according to recent new strategies of 'Quality by Design' and 'New Strategy for Process Validation Guidelines'. The tools included in this book are: expert systems; artificial intelligence tools, neuro-fuzzy tools, multimedia tools, artificial neural networks, neurofuzzylogic and genetic programming, plus other mathematical tools. Key Features: coverage of artificial intelligence tools, new expert systems, understanding of pharmaceutical processes, robust development of medicines, and new ways to develop medicines; development of drugs and medicines using mathematical tools. Contents: Artificial neural networks technology to model, understand, and optimize drug formulations; ME_expert 2.0: A heuristic decision support system for microemulsions formulation development; Expert system for the development and formulation of push pull osmotic pump tablets containing poorly water- soluble drugs; SeDeM Diagram: An expert system for preformulation, characterization and optimization of tablets obtained by direct compression; New SeDeM-ODT expert system: An expert system for formulation of orodispersible tablets obtained by direct compression; 3-D cellular automata in computer-aided design of pharmaceutical formulations: Mathematical concept and F-CAD software; OXPIRT: Ontology- based eXpert system for Production of a generic Immediate Release Tablet; Optimisation of compression parameters with AI-based mathematical models.