Elsevier NMR Metabolomics in Cancer Research (Woodhead Publishing Series in Biomedicine)

NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Key Features: focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics; current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications; information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types Contents: Biology Cancer metabolic phenotype; Experimental methodology; Metabolomics NMR data pre-processing Analysis of individual spectrum; Metabolomics data analysis Processing and analysis of a dataset; Dynamic metabolic profiling and metabolite network and pathways modelling; Biomarker discovery; NMR metabolomics application by cancer type; Perspectives.