Woodhead Publishing Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology (Woodhead Publishing Series in Biomedicine)

Stochastic kinetic methods are currently considered to be the most realistic and elegant means of representing and simulating the dynamics of biochemical and biological networks. Deterministic versus stochastic modelling in biochemistry and systems biology introduces and critically reviews the deterministic and stochastic foundations of biochemical kinetics, covering applied stochastic process theory for application in the field of modelling and simulation of biological processes at the molecular scale. Key Features: introduces mathematical concepts and formalisms of deterministic and stochastic modelling through clear and simple examples; presents recently developed discrete stochastic formalisms for modelling biological systems and processes; describes and applies stochastic simulation algorithms to implement a stochastic formulation of biochemical and biological kinetics. Contents: Deterministic chemical kinetics; The stochastic approach to biochemical kinetics; The exact stochastic simulation algorithms; Modelling in systems biology; The structure of biochemical models; Reaction-diffusion systems; KInfer: A tool for model calibration; Modelling living systems with BlenX; Simulation of ecodynamics: Key nodes in food webs.