Protein Folding in Silico: Protein Folding Versus Protein Structure Prediction (Woodhead Publishing Series in Biomedicine) - Image 1

£115.00

Woodhead Publishing Protein Folding in Silico: Protein Folding Versus Protein Structure Prediction (Woodhead Publishing Series in Biomedicine)

Name: Protein Folding in Silico: Protein Folding Versus Protein Structure Prediction (Woodhead Publishing Series in Biomedicine)
Brand: Woodhead Publishing
Price: 115.0 GBP
Availability: InStock

Biomedical Engineering

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Description

Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The opening chapters discuss the early stage intermediate and late stage intermediate models, followed by a discussion of structural information that affects the interpretation of the folding process. The second half of the book covers a variety of topics including ligand binding site recognition, the "fuzzy oil drop" model and its use in simulation of the polypeptide chain, and misfolded proteins. The book ends with an overview of a number of other ab initio methods for protein structure predictions and some concluding remarks. Key Features: discusses a range of ab initio models for protein structure prediction; introduces a unique model based on experimental observations. Contents: The early-stage intermediate; The late-stage intermediate; Structural information involved in the interpretation of the stepwise protein folding process; The divergence entropy characterizing the internal force fi eld in proteins; Ligand-binding-site recognition; Use of the fuzzy oil drop model to identify the complexation area in protein homodimers; Simulation of the polypeptide chain folding process using the fuzzy oil drop model; Misfolded proteins; A short description of other selected ab initio methods for protein structure prediction; Conclusion. About the Author Dr Irena Roterman-Konieczna heads the bioinformatics group at the Jagiellonian University Medical College and the Faculty of Physics, Astronomy and Applied Computer Science. Her background is in theoretical chemistry, and her research focuses on bioinformatics, with specific focus on protein structure prediction.

Product Specifications

Brand: Woodhead Publishing
Format: hardcover
ASIN: 1907568174
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Allied Health Professions > Biomedical Engineering
Domain: Amazon UK
Release Date: 04 October 2012
Listed Since: 15 September 2011

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Woodhead Publishing Protein Folding in Silico: Protein Folding Versus Protein Structure Prediction (Woodhead Publishing Series in Biomedicine)

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