Scion Publishing Bioinformatics: Methods Express (Life Science)

Bioinformatics: Methods Express is unique. It is a book on bioinformatics that makes sense to non-bioinformaticians. Bioinformatics: Methods Express helps you answer common questions such as: *what else is similar to my gene?; *does this protein have any transmembrane regions?; *how do I visualize an alignment between these DNAs?; *where can I find specific transcription factor sequences? The book provides the clear advice and explicit protocols that non-bioinformaticians need in order to understand what to do - and how to avoid common pitfalls. Each chapter guides you through the major databases and tools with worked examples - all accompanied by sample data files available online. Topics covered include: *data access; *sequence searches and alignments; *identification and annotation of features; *the transcriptome; *protein structure and function; *comparisons and phylogeny. Bioinformatics: Methods Express is a comprehensive manual for all wet-bench scientists who need to use bioinformatics - from postgraduate student to principal investigator. www.scionpublishing.com/bioinformatics contains comprehensive datasets which allow the reader to practise the techniques described in the book. Contents INTRODUCTION (Paul H. Dear); 1. Database resources for wet-bench scientists (Neil Hall and Lynn Schriml); 2. Navigating sequenced genomes (Melody Clark and Thomas Schlitt); 3. Sequence similarity searches (Jaap Heringa and Walter Pirovano); 4. Gene prediction (Marie-Adele Rajandream); 5. Prediction of non coding transcripts (Alex Bateman and Sam Griffiths-Jones); 6. Finding regulatory elements in DNA sequence (Debraj GuhaThakurta and Gary Stormo); 7. Expressed sequence tags (Arthur Gruber); 8. Protein structure, classification and prediction (Arthur Lesk); 9. Gene ontology (Vineet Sangar); 10. Prediction of protein function (Rodrigo Lopez); 11. Multiple sequence alignment (Burkhard Morgenstern); 12. Inferring phylogenetic relationships from sequence data (Peter Foster); Appendix; Index. Note from the Publisher: The following titles in the Methods Express series may also be of interest: Biosensors, Cell Imaging, DNA Microarrays, Expression Systems, Immunohistochemistry, PCR, Proteomics, and Whole Genome Amplification.