Elsevier Surfaces and Interfaces for Biomaterials (Woodhead Publishing Series in Biomaterials)

This book presents our current level of understanding on the nature of a biomaterial surface, the adaptive response of the biomatrix to that surface, techniques used to modify biocompatibility, and state-of-the-art characterisation techniques to follow the interfacial events at that surface. Key Features: complete coverage on the fundamentals of surface structure and forming to biological and clinical outcomes; includes reviews of key surface analytical techniques; edited by a renowned expert and written by an international team of authors. Contents: Part 1 Forming methods: Fundamental properties of surfaces; Control of polymeric biomaterial surfaces; Organic thin film architectures: fabrication and properties; Membranes and permeable films; Stable use of biosensors at the sample interface; Micro- and nanoscale surface patterning techniques for localising biomolecules and cells: the essence of nanobiotechnology. Part 2 Measurement, monitoring and characterisation: Surface spectroscopies; Surface microscopies; Nanoidentation; Surface plasmon resonance; Ellipsometry for optical surface study applications; Neutron reflection; Microgravimetry. Part 3 Surface interactions and in-vitro studies: Interaction between biomaterials and cell tissues; Blood flow dynamics and surface interactions; Cell guidance through surface cues; Controlled cell deposition techniques; Biofouling in membrane separation systems. Part 4 Surface interactions and in-vivo studies: Bioactive 3D scaffolds in regenerative medicine: the role of interface interactions; Intravascular drug delivery systems and devices: interactions at biointerface; Surface degradation and microenvironmental outcomes; Microbial biofilms and clinical implants; Extracellular matrix molecules in vascular tissue engineering; Biomineralisation processes; On the topographical characterisation of biomaterial surfaces. Part 5 Appendices: Surface modification of polymers to enhance biocompatibility; Issues concerning the use of assays of cell adhesion to biomaterials; Protein adsorption to surfaces and interfaces.