Royal Society of Chemistry Stem Cell-Based Tissue Repair

This unique book by leading experts reviews the key therapeutic issues related to stem cell technology. From the Back Cover Regenerative medicine is a relatively new field of medical science with vast potential in different clinical applications. Stem Cell-Based Tissue Repair presents a wide range of approaches on stem cell-based regenerative medicine. The first part of the book introduces the reader to the history and different aspects of basic and applied stem cell research. It presents different sources of progenitor or stem cells whilst comparing their abilities. The difficulties in the practical derivation and application of stem cells from different sources are discussed. A more comprehensive overview of stem cell-based and matrix association in the attempt to regenerate organs with stem cell engineering is presented in parts two and three. The advantages and problems associated with the interactions of stem cells with different scaffold matrices, the differentiation potential of stem cells and the major difficulties associated with the application of stem cells for clinical practice are discussed. Issues relating to stem cell-based tissue regeneration and the possible immunomodulation and homing of stem cells and issues relating to the ability to establish good manufacturing practice are also addressed. The contributors to this book include experts from a wide range of different areas of regenerative medicine. They present their different points-of-view and possible approaches for tissue regeneration, as well as relevant considerations on how to incorporate the wide range of stem cell sources in different regenerative treatment regimens. It will be a valuable reference resource for students and researchers involved in cell biology, tissue engineering and regenerative medicine. About the Author Raphael Gorodetsky is Professor at the Hadassah-Hebrew University Medical Center in Jerusalem. He heads a multi-focus research group at Hadassah Hospital that investigates issues in tissue regeneration and adult stem cell isolation, expansion, differentiation and implantation. He is also the Co-founder and Chief Scientist of Hapto Biotech Israel, Ltd, a start up company at Hadassah Hospital that has now merged with Forticell Biosciences NY. Professor Gorodetsky received his B.Sc. in Biology, M.Sc. in Physiology, Neurobiology Physiology & Medical Physics, and PhD in Biophysics and Biomedical Studies from the Hebrew University at Hadassah. He then held a post doctoral research position in Experimental Radiobiology at the UCLA Medical Center. His work there centred on the effects of radiation on normal tissue regeneration and wound healing. He is also the author of more than 85 peer reviewed manuscripts and a number of book chapters. He holds numerous patents in different fields and has been invited to lecture at many leading international conferences. Dr Richard Schõfer is a specialist in internal and transfusion medicine. He is a scientist at the Department of Stem Cell and Regenerative Biology at Harvard University, Cambridge, USA. He also heads the Mesenchymal Stem Cell Laboratory of the Institute of Clinical and Experimental Transfusion Medicine at the University Hospital T³bingen in Germany. His work there centres on tissue regeneration and adult stem cell isolation, expansion, differentiation and transplantation. He is also head of an interdisciplinary working group on Molecular Stem Cell Imaging (MSCI). Excerpt. © Reprinted by permission. All rights reserved. Stem Cell-Based Tissue Repair By Raphael Gorodetsky, Richard Schäfer The Royal Society of Chemistry Copyright © 2011 The Royal Society of Chemistry All rights reserved. ISBN: 978-1-84973-001-3 Contents Chapter 1 Promises and Limitations in the Application of Cell Therapy for Tissue Regeneration Raphael Gorodetsky, 1, Chapter 2 Adult Non-hematopoietic Stem Cells and Progenitor Cells (aNHSCs) R. Schäfer and L. Dahéron, 22, Chapter 3