Elsevier Drug Device Combination Products: Delivery Technologies and Applications (Woodhead Publishing Series in Biomaterials)

Drug delivery systems represent a vast area of research and development within biomaterials and medicine and the demand for sophisticated drug delivery devices continues to drive developments. Advanced drug delivery devices can offer significant advantages to conventional drugs, such as increased efficiency and convenience. Chapters in part one discuss specific applications such as drug eluting stents and antimicrobial cements. Part two covers the development of drug device combination products with such topics as preclinical testing and regulation of products. This book will provide a thorough analysis of the fundamentals, applications and new technologies of drug-device combination products for use throughout the human body. Key Features: illustrates how effective drug delivery can be achieved by means other than tablets providing readers with a comprehensive introduction and background to the field; provides a thorough analysis of the fundamentals, applications and new technologies of drug device combination products; discusses areas of application such as catheter based products and reviews the development of drug device combination products including pre-clinical testing and sterilisation. Contents: Part 1 Overview: Drug-device combination products; Enabling drug delivery from combination products; Nanomedical drug-device combination products. Part 2 Areas of application: Catheter-based drug-device combination products: an overview; Catheter-based drug-device combination products: the anti-infective 5-fluorouracil-coated central venous catheter; Future outlook for drug eluting stents (DES); Drug eluting beads (DEB) in the treatment of liver cancer; Antibiotic-loaded bone cements; Glass-ionomer cements as drug-device combination products; Bone graft substitutes as drug-device combination products; Antibacterial releasing dental restorative materials; Collagen-based dressings as therapeutic agents for wound healing; Drug-device combination products for occular applications. Part 3 Development of drug-device combination products: Safety and efficacy issues in designing drug-device combination products: the case of drug eluting stents (DES); Preclinical testing of drug-device combination products; Sterilisation of drug-device combination products; Innovation and patent issues in the development of drug-device combination products: the case of drug eluting stents (DES); Regulation of drug-device combination products in Europe; (28a) Regulation of drug-device combination products in the USA. About the Author Andrew Lewis is Research & Technology Director for Biocompatibles UK Ltd and Visiting Professor of Biomaterials & Drug Delivery at the University of Brighton.