The Pacemaker Channels Of The Heart: From Reductionism To Systems Biology - Image 1

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World Scientific Publishing Company The Pacemaker Channels Of The Heart: From Reductionism To Systems Biology

Name: The Pacemaker Channels Of The Heart: From Reductionism To Systems Biology
Brand: World Scientific Publishing Company
Price: 62.93 GBP
Availability: InStock

Cardiovascular

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Description

In The Pacemaker Channels of the Heart, Denis Noble chronicles the fascinating journey of his research into one of biology's most essential functions — the rhythmic beating of the heart. Written by the founder of mathematical heart modelling, this book traces scientific developments spanning over sixty-five years, from the pioneering 1960 heart rhythm model to the sophisticated integrative models of today. This journey follows the evolution of cardiac electrophysiology through the discovery of potassium and slow channels, analytical modelling, and the development of the electrocardiogram. Beyond its technical scope, the book describes a profound shift in biological thinking — from a reductionist, gene-centric view of life to a systems-based understanding of living organisms. In doing so, it addresses major philosophical and scientific debates surrounding the foundations of biology, offering a fresh perspective on why genes alone cannot account for the complexity of life. The book will be of great interest to researchers and students specialising in cardiology, as well as philosophers of science and more general readers, presenting a synthesis of rigorous research, theoretical innovation, and wider reflections on a storied career in the biological sciences. Contents: About the Author; Introduction; Discovery of Potassium Channels and the First Heart Cell Model; Discovery of Multiple Slow Channels; Analytical Mathematics of Excitable Cells; Insight into the T Wave of the Electrocardiogram; The Surprising Heart; Understanding Robustness in Biological Systems; The Physiome Project; 50 Years On; Systems Biology and The Music of Life; 65 Years On: Understanding Living Systems; Postscript: The Artist Disappears?; Glossary of Electrophysiology; Index;

Product Specifications

Brand: World Scientific Publishing Company
Format: hardcover
ASIN: 1800618115
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Cardiovascular
Domain: Amazon UK
Release Date: 10 October 2025
Listed Since: 10 June 2025

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World Scientific Publishing Company The Pacemaker Channels Of The Heart: From Reductionism To Systems Biology

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