Royal Society of Chemistry Drug Transporters: Volume 2: Recent Advances and Emerging Technologies: Volume 55 (Drug Discovery Series)

Excerpt. © Reprinted by permission. All rights reserved. Drug Transporters Volume 2 Recent Advances and Emerging Technologies By Glynis Nicholls, Kuresh Youdim The Royal Society of ChemistryCopyright © 2016 The Royal Society of Chemistry All rights reserved. ISBN: 978-1-78262-866-8 Contents Volume 1: Role and Importance in ADME and Drug Development, Section I: The Role of Transporters in ADME, Chapter 1 Membrane Transporters: Fundamentals, Function and Their Role in ADME John Keogh, Bruno Hagenbuch, Caroline Rynn, Bruno Stieger and Glynis Nicholls, 3, Chapter 2 Drug Transporters in the Liver: Their Involvement in the Uptake and Export of Endo- and Xeno-biotics Bruno Stieger and Bruno Hagenbuch, 57, Chapter 3 Drug Transporters in the Intestine Bente Steffansen, 81, Chapter 4 Drug Transporters in the Kidney Git Weng Chung, Sarah Faye Billington, Sarah Elizabeth Jenkinson and Colin Douglas Brown, 109, Chapter 5 Drug Transporters at the Blood-Brain Barrier David Dickens, Steffen Radisch and Munir Pirmohamed, 151, Chapter 6 Drug Transporters in the Lung: Expression and Potential Impact on Pulmonary Drug Disposition Lena Gustavsson, Cynthia Bosquillon, Mark Gumbleton, Tove Hegelund-Myrback, Takeo Nakanishi, Dan Price, Ikumi Tamai and Xiao-Hong Zhou, 184, Section II: Preclinical Models in Current Use within the Pharmaceutical Industry, Chapter 7 The Characteristics, Validation and Applications of In silico and In vitro Models of Drug Transporters Pradeep Sharma, Mohammed I. Atari, Robert Elsby, Simon Thomas, Simone Stahl, Constanze Hilgendorf and Katherine Fenner, 231, Chapter 8 Knockout and Humanised Animal Models to Study Membrane Transporters in Drug Development Nico Scheer, Xiaoyan Chu, Laurent Salphati and Maciej J. Zamek-Gliszczynski, 298, Chapter 9 Mechanistic Modelling to Predict Transporter-mediated Drug Disposition and Drug-Drug Interactions Rui Li, Krishna K. Machavaram, Simon Thomas and Manthena V. Varma, 333, Section III: Importance and Clinical Impact of Transporter-mediated Drug-Drug Interactions, Chapter 10 Transporter Drug–Drug Interactions: A Pharmaceutical Industry Perspective Silke Simon, Mohammed Ullah, Robert van Waterschoot, Dietmar Schwab, Susan Grange, Caroline A. Lee and Christoph Funk, 363, Chapter 11 Transporter Drug-Drug Interactions: Regulatory Requirements and Drug Labelling Susan M. Cole, Gustav Ahlin, Naomi Nagai, Daisuke Iwata, Masanobu Sato and Kenta Yoshida, 418, Subject Index, 450, Volume 2: Recent Advances and Emerging Technologies, Chapter 1 Emerging Transporter Science and Challenges for the Future Glynis Nicholls and Kuresh Youdim, 1, Chapter 2 Enabling Dynamic Response to Chemical Challenge: Nuclear Receptor-mediated Control of Transporter Expression Nick Plant, 19, Chapter 3 Targeted Proteomics to Support Transporter IVIVE and PBPK Aki T. Heikkinen, Neil Parrott, Tom Dunkley and Paul Cutler, 44, Chapter 4 Interplay Between Enzymes and Transporters: Impact on the Prediction of Pharmacokinetics and Drug-Drug Interactions Karelle Menochet and Hugues Chanteux, 73, Chapter 5 Pharmacogenomics of Drug Transporters: Clinical Implications Ichiro Ieiri, 114, Chapter 6 The Role of In vivo Imaging in the Study of Transporter Interactions in Animals and Humans Glynis Nicholls, Heather Flynn and Neil Woodhouse, 143, Chapter 7 Methods and Resources for Transport Proteins in Bioinformatics and Cheminformatics David Marcus and Lora Mak, 195, Subject Index, 227, CHAPTER 1 Emerging Transporter Science and Challenges for the Future GLYNIS NICHOLLS AND KURESH YOUDIM Introduction The role of membrane transporters in drug pharmacokinetics (PK) is now well established, even though in many respects it is still an emerging science, with our knowledge base continuing to expand. To date, the primary focus has been on the development of methods and models that identify the specific transporters involved in clinically relevant drug-drug interactions (DDIs), to elucidate their role in the disposition of a specific