Human Papillomavirus Vaccines

Cervical cancer is one of the most important neoplastic diseases of women worldwide and a major cause of premature female death in developing countries. This book addresses the two vaccines against HPV infection that have become commercially available in recent years. The vaccines are very effective in preventing infections with the two major cancer-causing genotypes, HPV-16 and HPV-18, and the cervical precancerous lesions that originate from such infections. The book outlines the pathobiology and immunology of human papillomavirus, the clinical data and safety and tolerance issues. Public health and clinical guidelines are also explored. The authors are among the most knowledgeable clinical and basic scientists in the fields of HPV immunology and pathogenesis, epidemiology and infectious diseases.