£81.32

About as cheap as it gets — within 5% of the all-time low it hit 2 months ago.

£81 today · all-time low £80 (Aug 2026) · usually the usual

Nova Science Publishers Inc Current Status of Proinflammatory Cytokines in Periodontal Disease & During Periodontal Therapy

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£90.58 £78.80 £81.37 £83.94 £86.51 £89.08 £91.65 25 July 2026 06 August 2026 18 August 2026 30 August 2026 12 September 2026
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Price Distribution

Price distribution over 50 days • 3 price levels

Days at Price
Current Price
13 days 36 days · current 1 day 0 9 18 27 36 £80 £81 £91 Days at Price

Price Analysis

Most common price: £81 (36 days, 72.0%)

Price range: £80 - £91

Price levels: 3 different prices over 50 days

Description

Periodontal diseases are chronic infectious diseases characterised by a destructive inflammatory process affecting the supporting tissues of the tooth. Numerous bacterial species have been isolated from subgingival plaque, which are closely associated with disease onset and progression. At the same time, there is strong evidence that destructive processes occurring as part of the host inflammatory response are responsible for the majority of the hard- and soft-tissue breakdown leading to the clinical signs of periodontitis. The characteristic clinical signs of chronic periodontitis occur mainly as a result of activation of host-derived immune and inflammatory defense mechanism. IL-1 and TNF induce expression of other mediators that amplify the inflammatory response, such as prostaglandins, and lead to production of lytic enzymes and stimulate the production of chemokines. Depending on its function, the cytokines have been classified into those which initiate and maintain inflammatory process, labelled as pro-inflammatory cytokines and those which exert an inhibitory effect on the immunologic response. These negative regulators, categorized as antiinflammatory cytokines, include IL -4 and IL -10, inhibitors such as IL -1 receptor, antagonist soluble IL -1 and TNF receptors that act as competitive blockers under pathologic conditions such as those that occur in periodontal disease. Noteworthy is the fact that cytokines which play an important role in inflammatory responses are also prominent regulators of normal tissue homeostasis. In fact, mRNA expression of cytokines that have been associated with periodontitis was constitutively detected, to some extent, in clinically healthy gingival tissues. The complex interaction of the cytokines at the molecular level is yet to be fully mapped. Additionally, further research pertaining to the other accessory arms of the cytokine network, such as the tissue metalloproteinases, the components involved in the acute phase of immunity as well as wound healing will augment the future of treating human periodontal disease via immunotherapy by modulating/ controlling the key pro-inflammatory cytokines.

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